Publications

 

Feigin ME*, Garvin T*, Bailey P, Waddell N, Chang DK, Shuai S, Gallinger S, McPherson JD, Grimmond SM, Khurana E, Stein LD, Biankin AV, Schatz MC, Tuveson DA. Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma. Nature Genetics. 2017 (*Co-first authors)     LINK    PDF

 

Feigin ME and Tuveson DA. Challenges and opportunities in modeling pancreatic cancer. Cold Spring Harb Symp Quant Biol. 2017    LINK    PDF

 

Baker L, BeGora M, Yeung FA, Feigin ME, Rosenberg A, Lowe S, Kislinger T, Muthuswamy SK. Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland. J Cell Sci. 129(12), 2307-15, 2016    LINK    PDF

 

Boj SF, Hwang C, Baker LA, Chio IIC, Engle DD, Corbo V, Jager M, Ponz-Sarvise M, Tiriac H, Spector MS, Gracanin A, Oni T, Yu KH, van Boxtel R, Huch M, Rivera KD, Wilson JP, Feigin ME, Öhlund D, Handly-Santana A, Ardito-Abraham CM, Ludwig M, Elyada E, Alagesan B, Biffi G, Yordanov GN, Delcuze B,Creighton B, Wright K, Park Y, Morsink FHM, Molenaar IQ, Rinkes IHB, Cuppen E, Hao Y, Jin Y, Nijman IJ, Iacobuzio-Donahue C, Leach SD, Pappin DJ, Hammell M, Klimstra DS, Basturk O, Hruban RH, Offerhaus GJ, Vries RGJ, Clevers H, Tuveson DA. Organoid models of human and mouse ductal pancreatic cancer. Cell. 160(1-2), 324-38, 2015    LINK    PDF

 

Feigin ME*, Xue B, Hammell MC, Muthuswamy SK*. G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion. PNAS. 111(11), 4191-4196, 2014 (*Co-corresponding authors)    LINK    PDF

Selected as Science Editor’s Choice (LINK), PNAS Weekly Highlights (LINK)

 

Feigin ME, Akshinthala SD, Araki K, Rosenberg AZ, Muthuswamy LB, Martin B, Lehmann BD, Berman HK, Pietenpol JA, Cardiff RD, Muthuswamy SK. Mislocalization of the polarity protein Scribble promotes mammary tumorigenesis and is associated with basal breast cancer. Cancer Research. 74(11), 3180-3194, 2014    LINK    PDF

 

Feigin ME. Harnessing the genome for characterization of GPCRs in cancer pathogenesis. (Review) FEBS  Journal. 280, 4729-4738, 2013    LINK    PDF

 

Chatterjee S, Seifried L, Feigin ME, Gibbons DL, Scuoppo C, Lin W, Rizvi ZH, Lind E, Dissanayake D, Kurie J, Ohashi P, Muthuswamy SK. Dysregulation of cell polarity proteins synergize with oncogenes or the microenvironment to induce invasive behavior in epithelial cells. PLoS ONE. 7(4):e34343, 2012    LINK    PDF

 

Feigin ME and Muthuswamy SK. Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis (Review). Curr Opin Cell Bio. 21(5), 694-700, 2009    LINK    PDF

 

Feigin ME and Muthuswamy SK. ErbB receptors and cell polarity: New pathways and paradigms forunderstanding cell migration and invasion (Review). Exp Cell Res. 315(4), 707-16, 2009    LINK    PDF

 

Bikkavilli RK, Feigin ME and Malbon CC. p38 mitogen activated protein kinase regulates canonical Wnt/β-catenin signaling by inactivation of GSK3β. J Cell Sci. 121(21), 3598-607, 2008    LINK    PDF

 

Feigin ME and Malbon CC. OSTM1 regulates b-catenin/Lef1 interaction and is required for Wnt/b-catenin signaling. Cell Signal. 20(5), 949-57, 2008 (Corresponding author)    LINK    PDF

 

Bikkavilli RK, Feigin ME and Malbon CC. G(alpha)o mediates Wnt/c-Jun N-terminal kinase signaling via Dvl 1,3/RhoA family members/MEKK1,4 in mammalian cells. J Cell Sci. 121(2), 234-45, 2008    LINK    PDF

 

Feigin ME and Malbon CC. RGS19 regulates Wnt/beta-catenin signaling through inactivation of G(alpha)o. J Cell Sci.120(19), 3404-14, 2007 (Corresponding author)    LINK    PDF